Transmural dispersion of repolarization: a complementary index for cardiac inhomogeneity

To the editor  We read the article written by Nuis, et al. The authors investigated the effects of transcatheter aortic valve implantation (TAVI) on corrected QT dispersion (cQTD) in severe aortic stenosis patients. They concluded that, 40% of patients had defective cQTD recovery at six months after the procedure and this was associated with increased late mortality risk. We would like to contribute to the study from a different methodological perspective. In this study, the percentages of defective cQTD patients were higher than we expected. This findings were interesting because previous studies had shown that, aortic balloon valvuloplasty and surgical aortic valve implantation were associated with cQTD recovery. Moreover, Erkan, et al. have reported that TAVI procedure reduced QT dispersion six months after the intervention. This inconsistency may be attributed to measurement differences. We appreciate the magnification of ECG recordings to 50 mm/s and evaluating with two different observers. However, according to our experiences, manual ECG measurement is extremely difficult. It would have been better if the authors had transferred ECG recordings to the digital platform in order to obtain more precise data. QT dispersion is the most frequently used parameter to determine ventricular homogeneity and arrhythmia risk. However, there are some technical difficulties of QT dispersion measurement. For example, it has low reproducibility, thereby the interor intra-observer variabilities are very high. In addition, determination of the end of the T wave in some ECG leads such as V1, V2 or aVF is frequently difficult. Alternatively, transmural dispersion of repolarization (TDR) have been using for ventricular arrhythmia prediction over past decade. Briefly, myocardium consists of three